Summary
The Center for Drug Discovery (
https://www.bcm.edu/research/centers/drug-discovery
) is a strategic research center at Baylor College of Medicine in
Houston, Texas. We are currently seeking highly motivated,
well-organized and enthusiastic Postdoctoral Fellows contributing
to our research in the fields of drug metabolism and toxicity, as
well as the study of chemical properties that aid in crossing the
blood-testis barrier (BTB). In our well-equipped laboratory, we
utilize advanced instruments such as Thermos UHPLC-Q Exactive MS,
Orbitrap Exploris™ 120, Thermo Quintus (triple quadruple), and
Imaging mass spectrometry (IMS, Bruker timsTOF fleX MALDI-2) to
conduct LC-MS-metabolomics, pharmacokinetics, and spatial
metabolomics. Understanding the drug metabolism could predict the
possible adverse events of drugs in clinic and also could reduce
the risk of the drug candidates in drug development. Determining
chemical features passing BTB will facilitate the drug development
for therapeutic targets behind BTB. Baylor College of Medicine is
located in the prestigious Texas Medical Center and offers a highly
interactive environment and a strong infrastructure for research
and career development. To obtain further details about the
positions, feel free to email Dr. Feng Li (
fl3@bcm.edu ) directly.
Job Duties
- Plans, designs and conducts experiments.
- Characterizes the drug metabolites using High-resolution LC-MS
and NMR.
- Analyzes LC-MS data from mouse tissue and plasma to evaluate
their abilities for passing through BTB.
- Documents and interprets experimental results and report to
principal investigators.
- Conducts literature searches and summarizes information in an
appropriate format for a particular study.
- Helps to write and prepare manuscripts.
- Performs other job related duties as assigned.
Minimum Qualifications
- MD or Ph.D. in Basic Science, Health Science, or a related
field.
- No experience required.
Preferred Qualifications
- Doctoral degree in Chemistry, Drug metabolism and
pharmacokinetics, Pharmacology, and Toxicology, or a related
Biomedical Science discipline.
- Experience in medicinal chemistry and structural
characterization using LC-MS and NMR.
- Skilled in the identification of drug metabolites in vitro and
in vivo.
- Experience in working with animals, including animal treatment
and tissue collection.
- Have the ability to plan, design and conduct experiments,
especially on drug metabolism, tissue distribution, and metabolites
identification. Pharmacology and toxicology backgrounds is a
plus.
- Have the experience of preparing and writing the
manuscript.
- Have experience in LC-MS method development and sample
preparation, and data analysis
Baylor College of Medicine is an Equal Opportunity/Affirmative
Action/Equal Access Employer.
PD; SN
Requisition ID: 21280
